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This work provides comprehensive coverage of the recent progress on designing and developing iron oxide-based nanomaterials through a green synthesis strategy, including the use of benign solvents and ligands. Despite the limitations of nanotoxicity and environmental risks of iron oxide-based nanoparticles for the ecosystem, this critical review presents a contribution to the emerging knowledge concerning the theoretical and experimental studies on the toxicity of MIONs. Potential improvement of applications of advanced i