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Despite the advantages connected with functionalization of MWCNT, especially in overcoming issues concerning solubility, a few research reports have shown that these functionalized nanoparticles show different poisoning profiles. Because of this study, we aim to compare NR8383 cells answers to three well-characterized MWCNT with different functional teams. This research employed cytotoxicity assays, transcriptomics and proteomics to evaluate their toxicity using NR8383 ra