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New analysis shows the same property during the Ebola virus outbreak. At a computational level, we improved the alignment-free method to identify pathogen-specific signatures in balance with GC measures and removed previous size limitations. https//github.com/cobilab/eagle. Supplementary data are available at Bioinformatics online. Supplementary data are available at Bioinformatics online.Neutrophil adhesion and extravasation into tissue at sites of injury or infection depend on binding of the integrin lymphocyte function-associated antig