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minimally invasive surgery. This overview of the history of liver surgery over the past 50 years may provide useful insights for further innovation in the next 50 years. © 2020 The Authors. Annals of Gastroenterological Surgery published by John Wiley Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterology.Although upfront surgery has been the gold standard for pancreatic adenocarcinoma that is planned for resection, it should be compared with the alternative strategy of neoadjuvant therapy. Despite the many re
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