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addressing HBV and its disease burden. Copyright © 2020 American Society for Microbiology.Heat shock protein 47 (HSP47) is a collagen-specific protein chaperone expressed in fibroblasts, myofibroblasts and stromal cells. HSP47 is also expressed in and involved in growth of cancer cells in which collagen levels are extremely low. However, its role in cancer remains largely unclear. Here, we showed that HSP47 maintains cancer cell growth via the unfolded protein response (UPR), the activation of which is well known to be induced b