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Classification along these properties suggests different roles of TA systems and highlights the association and co-evolution of toxins and antitoxins. © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.Recent advances in high-throughput single-cell RNA-seq have enabled us to measure thousands of gene expression levels at single-cell resolution. However, the transcriptomic profiles are high-dimensional and sparse in nature. To address it, a deep learning framework based on auto-encoder, termed D