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Computational results show that the Np-L covalent interactions in Np IV L 2 are similar to those in the Np VI O 2 L(MeOH) complex, indicating that neither the presence of the axial oxo ligands nor the oxidation state significantly modify the nature of the Np-L bonds.Thymic epithelial cells (TECs) are the main regulators of T lymphocyte development and selection, requiring a three-dimensional (3D) environment to properly perform these biological functions. The aim of this work was to develop a 3D culture substrate that allows the survival