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Introduction Self-compassion, a trait that involves responding to one's difficulties with care and concern, may offer unique stress coping benefits during the challenges of adolescence. Methods This cross-sectional study used survey data from a large adolescent sample within two U.S. school settings (N=1,057; 65% female; 68% white; mean age 14.7 years) to examine whether self-compassion buffers the impact of perceived stress on internalizing symptoms, and secondarily, if these relationships differ by gender. Results Regression analysis