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How Does Medication For ADHD Work? Stimulants are the most commonly prescribed ADHD drugs. They work by increasing the levels of brain chemicals called dopamine and norepinephrine. These include methylphenidate, amphetamines and dextroamphetamines (Adderall), and lisdexafetamine (Vyvanse). These are often prescribed in long-release formulation that lasts for between six and eight hours or more. This minimizes the up
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