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Mean±standard deviation (SD) ended up being pooled making use of a random-effects design. After the major search, away from 528 scientific studies identified, 16 studies were in concordance with predefined criteria and selected when it comes to last assessment. Among these, 12 scientific studies utilized viral manipulation, and 4 used non-viral vectors for gene delivery. The meta-analysis revealed gene therapy with a viral vector decreased mean IPGTT (-12.69 mmol/l, P less then 0.0