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12). No obvious publication bias was detected by Begg's test in all the analyses. The results drawn in our meta-analysis suggest that the presence of preoperative HN is associated with worse prognosis in patients treated with RNU for UTUC. Therefore, closer surveillance and more aggressive therapy may be needed for UTUC patients present with preoperative HN. Well-designed prospective studies are necessary to substantiate the prognostic value of HN in UTUC. The results drawn in our meta-analysis suggest that the presence of preoperative HN
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