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Adult ADHD and Comorbid Disorders Many people suffering from ADHD have comorbid conditions like major depression (Kessler and co., 2006). Many patients are not responsive to medication for depression and may be able to benefit from psychotherapy. Medications that most effectively improve the symptoms of ADHD appear to increase and balance levels of specific neurotransmitters, which are brain chemicals. Commonly prescribed stimulants include amphetamine, methylphenidate, and similar