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Does ADHD Medication Work? When someone gets a prescription for ADHD medication, they usually be concerned about whether the medication will work and how long it will last. Here are some simple answers. Stimulants alter brain chemicals that transmit messages about attention and activity. Dopamine, norepinephrine and other brain chemicals are also included. They are considered to be the first line treatment option for adults with ADHD. 1. Stimulants Stimulants are a