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Although the administration of single-allergen extracts is recommended, there are polysensitized patients who require a different strategy. This study evaluates the effectiveness of an extract containing a mixture of house dust mites (HDM) and mold allergens in polysensitized patients with asthma and/or rhinitis. Using validated questionnaires, we assessed asthma and rhinitis control and quality of life (QOL) of patients that received a combined immunotherapy of HDM and mold in routine clinical practice. 39 polysensitized patients with a