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Deletion of a cAMP-responsive CRE within the Per1 promoter blunted light-induced Per1 expression into the SCN through the night, while removal of an ATF4 (CREB-2)-associated CRE when you look at the Per2 promoter had no impact on its appearance. These outcomes recommended that the CRE when you look at the Per1 promoter works well with light induction although not CRE in the Per2 promoter. Behavioral rhythms noticed under some light problems are not impacted by
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