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Ribonucleases (RNases) can be viewed a course of RNA-binding proteins with nucleolytic task that are in charge of RNA maturation and/or degradation. Presently RNase E, RNase III, and PNPase appear to be the primary players not only in sRNA turnover but additionally in sRNA handling. Here we review the present knowledge in the most significant microbial RNA-binding proteins affecting sRNA activity and sRNA-mediated networks.The well-recognized