https://www.selleckchem.com/pr....oducts/acss2-inhibit
6-fold higher than in the hydroxylated framework, and an alcohol/ketone ratio of 5.6(3).Reports of C-H insertions forming six-membered rings containing heteroatoms are rare due to Stevens rearrangements occurring after nucleophilic attack on the carbene by a heteroatom. Using donor/donor carbenes and Rh2(R-PTAD)4 as a catalyst, we have synthesized a collection of isochroman substrates in good yield, with excellent diastereo- and enantioselectivity, and no rearrangement products were observed. Furthermore, we report the first syn
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