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ADHD Treatment For Adults stimulants such as amphetamine and methylphenidate help boost levels of certain brain chemicals. Non-stimulants such as atomoxetine and antidepressants perform slower than stimulants however, they can be as effective. Comorbid conditions can impact the effectiveness to ADHD medications. Doctors should treat the most severe symptoms of any comorbid disorder first, then monitor whether the ADHD symptoms improve. Medication The most commonly used method of treatment is medicatio