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05). Haplotype analysis results indicated that Trs11168100Ars353303Trs353300Crs353299 acts as a protective factor of esophageal cancer with OR of 0.71 (95% CI = 0.52-0.98, p = 0.038), while Ars11168100Grs353303Crs353300 and Ars11168100Ars353303 have 1.49-fold (OR = 1.49, 95% CI = 1.02-2.19, p = 0.041) and 1.57-fold (OR = 1.57, 95% CI = 1.05-2.35, p = 0.027) increased risk of esophageal cancer, respectively. CONCLUSION The results of our study suggested that CARMN variations may affect the risk of esophageal cancer. OBJECTIVE lacZ encod