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f life; TOV trial of voiding; (S)(U)UI (stress) (urge) urinary incontinence. To perform a systematic review and meta-analysis of available prospective and retrospective studies comparing the minimally invasive (laparoscopic or robot-assisted) simple prostatectomy (MISP) and laser enucleation of the prostate for treating male lower urinary tract symptoms in high-volume prostates, as laser enucleation of the prostate is the new trend for treating high-volume prostates (80 mL) but many urologists now prefer MISP. A systematic search was done using the Medi