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How to Choose the Best ADHD Medication for Adults Drugs that stimulate the brain such as methylphenidate or amphetamine boost and balance brain chemicals. Doctors prescribe them as pills, liquids or patches. Healthcare professionals also utilize drugs called norepinephrine reuptake inhibitors and alpha-2 agonists for treating ADHD. These are usually used "off-label" to treat this condition as they're FDA-approved to treat other ailments. Stimulants are among the most frequently ADHD medication prescribed. They increase the levels of brain chemicals norepinephrine