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The goal of this review would be to measure the role of GH receptor polymorphisms in skeletal fragility in patients suffering from GHD and acromegaly. In reality, so far, two various isoforms of this GH Receptor (GHR) had been described, that vary when it comes to presence or perhaps the absence of transcription for the exon 3 for the GHR gene. Both the isoforms produce a functioning receptor, nevertheless the exon 3-deleted isoforms (d3-GHR) has actually a greater sensitivity
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