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We also highlight advances in the development and preclinical validation of pharmacological compounds that target β-Klotho and/or the β-Klotho-FGFRs complex for the treatment of T2DM. Given the remarkable advances in this field, we also discuss outstanding research questions and the many challenges in the clinical development of β-Klotho-based therapies. There has been an alarming increase in colorectal cancer (CRC) incidence among young adults aged 50years, and factors driving this upward trend are unknown. This study investigated