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Our study establishes a novel canine model for CPHD with a candidate POU1F1 defect. Although physical therapy is the recommended treatment in patients over 45years old with a degenerative meniscal tear, 24% still opt for meniscal surgery. The aim was to identify those patients with a degenerative meniscal tear who will undergo surgery following physical therapy. The data for this study were generated in the physical therapy arm of the ESCAPE trial, a randomized clinical trial investigating the effectiveness of surgery versus physical the
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