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001), and hospitalization (1.21, CI 1.02-1.44, p = 0.032) were significantly higher in RF patients in usual care. Furthermore, there was a trend of more bleeding events in RF patients. CS-treated patients had significantly lower adjusted hazard ratios for death (0.24, CI 0.14-0.39, p less then 0.001), hospitalizations (0.41, CI 0.34-0.5, p less then 0.001), clinically relevant bleeding (0.29, CI 0.18-0.47, p less then 0.001), and major bleeding (0.33, CI 0.18-0.59, p less then 0.001). Thus, patients who required oral anticoagulation th