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Targeting ANP32B or its regulated pathways might therefore pose a new strategy to combat severe influenza. Copyright © 2020 Beck, Zickler, Pinho dos Reis, Günther, Grundhoff, Reilly, Mak, Stanelle-Bertram and Gabriel.The immune system plays a significant role in controlling systemic metabolism. Innate-like T (ILT) cells in particular, such as mucosal-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells and γδ T cell receptor expressing cells, have been reported to promote metabolic homeostasis. However, these diff