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Histological examinations by HE and CFV, while immunohistochemical analysis of astrocytes, P53 protein, and NSE were performed. Androgen deprived insulin-resistant state caused altered learning and cognitive behavior through decreased percentage correct alternation to an increased escape latency period. Significant bidirectional correlates exist between the hormonal profiles relative to the control group (p less then 0.05), especially in the 60 days post-orchiectomy. While histological and immunohistochemical data indicate microcel