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41, p 0.001). Weight gain ≥2kg on postoperative day 1 was also a risk factor (OR 1.76, p 0.001). A high BMI, a pancreaticojejunostomy and postoperative weight gain were risk factors for developing POPF. Diabetes or preoperative biliary drainage was protective. A high BMI, a pancreaticojejunostomy and postoperative weight gain were risk factors for developing POPF. Diabetes or preoperative biliary drainage was protective. Sphingolipids are a diverse class of lipids with various roles in cell functions and subclasses such as ceramides have b