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Observational, retrospective and cross-sectional study.Setting This study took place at the Neuroendocrinology Unit of Clinics Hospital, healthcare class of University of São Paulo, Brazil, a tertiary referral center. Research participants included grownups with sporadic prolactinomas addressed with cabergoline, where reaction to therapy had been defined by prolactin normalization with up to 3 mg/week amounts. DNA was obtained from bloodstream samples and the PRL-R end