https://www.selleckchem.com/pr....oducts/ver155008.htm
Based on the final model, the following values were estimated by NONMEM Cl = 5.15 L/h, Q (intercompartmental clearance) = 3.31 L/h, Cl = 0.0031 L/h, V = 42.1 L, V = 0.32 L and the value of V was fixed to 86.2 L. With the developed pharmacokinetic model, area under the curve (AUC) values as well as CSF trough levels were simulated. Based on our analysis, the dosing of vancomycin should be referred to the degree of inflammation (derived from the CSF lactate concentration) and renal function (derived from Cl ). Based on our analysis, the
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