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Pre-treatment of rats with doses of 50 and 100 mg/kg Mesalazine (5-ASA) in experimental teams 1 and 2 increased the pH of gastric liquid and paid down the gastric ulcer index set alongside the ethanolic group. Also, the results indicated that mesalazine, paid down the tissue reactive oxygen species (ROS), malondialdehyde (MDA), and necessary protein carbonyl (PCO) levels, serum nitric oxide (NO), and enhanced the level of structure NO and glutathione (G
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