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Medication For ADHD - What Are the Side Effects? Many people suffering from ADHD have their symptoms improved through medication. is different, and the side effects can be a problem. Methylphenidate is part of a class of drugs referred to as stimulants. It works by increasing levels of a chemical within the brain that aids in controlling attention and behavior. Stimulant drugs Stimulant drugs improve attention and concentration in 70% to 80percent of children and adults who use them. They affect the activity of neurotransmitters that are