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HSP47-C was 39% higher in ALD patients (median 17.7ng/mL, IQR 12.4-24.0ng/mL) compared to HC (median 12.7ng/mL, IQR 9.4-15.7ng/mL, p0.0001). In addition, HSP47-C was elevated in patients with severe fibrosis (F3-4, median 22.8ng/mL, IQR 17.5-33.3ng/mL) compared to none-to-moderate fibrosis (F0-2, median 16.5ng/mL, IQR 11.8-22.5ng/mL) with an AUROC of 0.72 (p0.0001). HSP47-C also correlated with other liver disease parameters, albumin, bilirubin and aspartate transaminase. We developed a competitive ELISA for serological detecti