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Increase of ciRS-7 and hsa_circ_0067934 was also related with advanced TNM stage. The biological effects depend on the general function of circRNA as microRNA sponge. CircRNAs have the potential to function as prognostic markers and are associated with lung cancer progression and metastasis. CircRNAs have the potential to function as prognostic markers and are associated with lung cancer progression and metastasis. This study is to investigate the role of neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CysC) and creatinin