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17 (1.10-1.25) per 10 µg·m for NO , and 1.15 (1.08-1.23) per 0.5 10 m for BC. Hazard ratios were larger in cohort subsets with exposure levels below the EU and US limit values and possibly WHO guidelines for PM and NO . NO and BC estimates remained unchanged in two-pollutant models with PM , whereas PM estimates were attenuated to unity. The concentration response curves showed no evidence of a threshold. Long-term exposure to air pollution, especially from fossil fuel combustion sources such as motorised traffic, was associated wi