https://www.selleckchem.com/pr....oducts/motolimod-vtx
Additionally, the TE domains preferentially cyclized polyketides that bore the expected oxidation state at the C-3 position, effectively bypassing non-cognate module directed reduction and altering the predicted catalytic sequence. Extending these findings led to formation of a novel metabolite containing a pyran ring instead of the predicted macrolactone. Collectively, these data provide new insights regarding the PKS TE as an important target for protein engineering to optimize polyketide analog assembly in engineered PKS p
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