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Therefore, this study reminds researchers of the presence of MAUP and the necessity to minimize this problem while exploring the environmental determinants of the COVID-19 outbreak.Objective Recent evidence indicates that inhibition of prolyl hydroxylase domain (PHD) proteins can exert beneficial effects to improve metabolic abnormalities in mice and humans. However, the underlying mechanisms are not clearly understood. This study was designed to address this question. Methods A pan-PHD inhibitor compound was injected into WT and liver