https://www.selleckchem.com/pr....oducts/cid-1067700.h
The synthesis of Asn-tRNAAsn in most prokaryotes uses an indirect aminoacylation pathway involving a non-discriminating aspartyl-synthetase (ND-AspRS) and a glutamine amidotransferase (GatCA. This was recently implicated as an adaptive mistranslation mechanism for antimicrobial resistance in Mycobacterium tuberculosis, but it remains poorly understood. We report an accessible liquid chromatography-mass spectrometry method with unparalleled chemical specificity, sensitivity, and quantification over the current assays to enable the
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