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Recognizing germline TRIM28 variants in patients with WT can enable counselling, genetic testing, and potential early detection of WT in other children in the family. A further exploration of TRIM28-associated WT will help to unravel the diverse and complex mechanisms underlying WT development. © 2021 The Authors. The Journal of Pathology published by John Wiley Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. Type 1 diabetes mellitus (T1DM) is a complex metabolic disorder characterized by hyperglycaem
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