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The impact of AF on the outcome of patients with PAD was greater in those with CLTI. Further studies are needed to clarify the possible mechanisms underlying these differences.Currently, the rapid socioeconomic development and urbanization around the world have caused the ecological environment on the earth surface to become extremely fragile and destroyed. In addition, the increasing demand of human beings for material also leads to the unsustainable development of resources and environment. However, how to achieve the win-win goal bet