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Together with molecular dynamics simulations, the structures also revealed how FUT8 dimerization plays an important role in defining the acceptor substrate-binding site. Collectively, this information significantly builds on our understanding of the core fucosylation process. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.Inhibition of BET protein bromodomains BD1 and BD2 produces unique phenotypes in disease models. ©2020 American Association for Cancer Research.Patients with HPV16+ cervical
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