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nce in rice. #link# Further study of ES2 will facilitate the dissection of the genetic mechanisms underlying early leaf senescence and plant growth. Clinicians are currently challenged to support older adults to maintain a certain level of Functional Independence (FI). FI is defined as "functioning physically safely and independent from another person, within one's own context". A Core Outcome Set was developed to measure FI. link2 The purpose of this study was to assess discriminative validity of the Core Outcome Set FI (COSFI) in a population of Dutch old