https://www.selleckchem.com/pr....oducts/PD-0332991.ht
What are the genetic causes of oocyte maturation defects? A homozygous splicing variant (c.788 + 3AG) in TATA-box binding protein like 2 (TBPL2) was identified as a contributory genetic factor in oocyte maturation defects. TBPL2, a vertebrate oocyte-specific general transcription factor, is essential for oocyte development. TBPL2 variants have not been studied in human oocyte maturation defects. Two infertile families characterized by oocyte maturation defects were recruited for whole-exome sequencing (WES). Genomic DNA was extra
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