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The results can serve to improve the work environment of carers, optimize the use of human resources and increase the visibility and efficiency of nursing work. To determine whether desirable diabetes control is associated with polypharmacy and to evaluate potential drug interactions (DI) in participants with diabetes mellitus in the Brazilian Longitudinal Study on Adult Health (ELSA-Brasil). This cross-sectional study included 1418 participants with medical diagnosis of diabetes at study baseline (2008-201. Polypharmacy was defined as