https://www.selleckchem.com/products/yk-4-279.html
Of note, among the genes we edited was the introduction of a T35A mutation in the proteasome subunit PSMB6, which eliminates its caspase-like activity. The edited cells showed a specific reduction in this activity, demonstrating this system's utility in generating cell lines with biologically relevant mutations in endogenous genes. This approach offers a rapid, efficient, and scarless method for selecting genome-edited cells requiring HDR.Duchenne muscular dystrophy (DMD) is an X-linked recessive progressive lethal disorder caused by t
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