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ADHD Treatment For Adults Stimulants like methylphenidate, amphetamine, and other brain chemicals can help increase levels. Nonstimulants, like antidepressants and atomoxetine, work slower than stimulants, but they can be beneficial too. Complicating conditions can affect the response of ADHD medications. The most severe symptoms from any comorbid condition should be treated first. Then, the physician should monitor whether ADHD symptoms improve.