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Even more studies are required to investigate the long-term effects of ECT also to further explain the different therapy outcomes between senior and younger clients.BACKGROUND Sepsis may be the overwhelming inflammatory reaction to infection, for which nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome plays a vital role. Shingosine-1-phosphate is reported to stimulate NLRP3 inflammasome activation. Sphingosine kinase 1 (SphK1) cou