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The aim of this study was to analyse four cohabitation challenge-test experiments with Mekong striped catfish (Pangasianodon hypophthalmus) against the bacterium Edwardsiella ictaluri. The data were genetically analysed per experiment by three models 1) a cross-sectional linear model; 2) a cross-sectional threshold model; and 3) a linear survival model, at both 50% mortality (for models 1 and 2) and at the end of the test (for all three models). In two of the experiments (3 and 4) that were carried out in two replicated tanks, the predicted