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Left atrial (LA) invasion by lung cancer via hematogenous pathways is relatively uncommon. Herein we report the case of a 68-year-old male without any medical history, in whom lung cancer was diagnosed by transesophageal echocardiographic detection of the LA and left ventricle tumoral invasion via the left upper pulmonary vein. The primary source of tumor was found out by computed tomography. © 2020 Wiley Periodicals, Inc.5-methyltetrahydrofolate (5-MTHF) is the major form of folate in human plasma and is the only folate form tha