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In contrast, inappropriate use was observed in 41% (95% CI 34-48%; 82/20 and unclear/other use was observed in 20% (95% CI 15-26%; 40/20. CONCLUSIONS and Relevance Reporting guidelines of health research studies are frequently used inappropriately. Authors may require further education around appropriate use of reporting guidelines in research reporting. AIM The enzyme 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with cardiac and pathological remodeling and ion channel function regulation. However, whether it r